Liver-to-plasma vaniprevir (MK-7009) concentration ratios in HCV-infected patients
نویسندگان
چکیده
منابع مشابه
Liver-to-plasma vaniprevir (MK-7009) concentration ratios in HCV-infected patients.
BACKGROUND Some drugs that are actively taken up into the liver exhibit greater than dose proportional increases in plasma exposure, although human liver-to-plasma concentration ratios have rarely been evaluated. Understanding these relationships has implications for drug concentrations at the target site for certain classes of compounds, such as direct-acting antivirals, targeted towards HCV. ...
متن کاملMK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.
The administration of hepatitis C virus (HCV) NS3/4A protease inhibitors to patients with chronic HCV infections has demonstrated that they have dramatic antiviral effects and that compounds acting via this mechanism are likely to form a key component of future anti-HCV therapy. We report here on the preclinical profile of MK-7009, an inhibitor of genotype 1a and 1b proteases at subnanomolar co...
متن کاملNon-invasive assessment of liver steatosis and fibrosis in HIV/HCV- and HCV- infected patients.
BACKGROUND Conflicting data have been reported on the prevalence of liver steatosis, its risk factors and its relationship with fibrosis in patients with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection or with HCV mono-infection. AIM The study aims were to assess steatosis prevalence and its risk factors in both HCV groups. We also evaluated whether steatosis was linke...
متن کاملLiver function parameters in HIV/HCV co-infected patients treated with amprenavir and ritonavir and correlation with plasma levels.
Acute liver toxicity is a frequent adverse event that occurs during antiretroviral therapy and was observed in 6-30% of the patients on treatment, especially in presence of HCV coinfection (Cooper et al., 2002, Maida et al., 2006, Sulkowski et al., 2000). A correlation between HCV-associated liver-fibrosis severity and the risk of HAART associated hepatoxicity has been demonstrated (Aranzabal e...
متن کاملMetabolic features in chronic HCV infected patients
Methods We conducted a cross-sectional analysis on chronic HCVinfected adult patients, monitored at the National Institute of Infectious Diseases “Prof. Dr. Matei Balş”. Patients with diabetes mellitus, chronic alcohol consumption, other chronic liver diseases, HBV or HIV co-infections were excluded. We recorded demographic data, HCV infection history, personal and family history of CVR factors...
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ژورنال
عنوان ژورنال: Antiviral Therapy
سال: 2015
ISSN: 1359-6535
DOI: 10.3851/imp2958